When the normalcy of our life ceases to exist, we can choose to either fill that vacuum with what God intended, Himself, or we can continue to give everything else a priority over Him. Therefore the "it" can be a doctor's diagnosis, or an accident, the loss of a friendship.
"It" can be the loss of a job or financial status. A common thread is that "it" is usually something that we either value or depend upon more than our relationship with God. And let's be clear, God allows suffering so that our lives will be saved, not to drive us into despair without hope. He is our hope, He is our King, and He refuses to share His throne with anyone or anything else.